Annually, urinary tract infections (UTIs) are responsible for more than 11 million physician visits in the United States. Although normally a commensal inhabitant of the intestinal and gastrointestinal tract of humans, Escherichia coli is the most common urinary-tract pathogen, whose overgrowth and overcolonization accounts for 85% of UTIs. Cranberries have been used as a medicinal agent for centuries to promote health, but recently the scientific literature has proven that proanthocyanidins, contained in cranberries, as well as a simple sugar, ᴅ‑mannose, specifically inhibit the adhesion and proliferation of E. coli in the urinary tract. Cranberry extracts and ᴅ‑mannose each independently inhibit one of two adhesion methods utilized by E. coli. Combined together in a synergistic and novel formula, D‑Mannose SAP addresses both type-1 (FimH) and P-type fimbrial-mediated adhesion by E. coli to the urinary tract mucosa. D‑Mannose SAP is specifically targeted for the treatment and prevention of E. coli UTI.